synthesis of 2 - butyl - 3 - (2 '- (1 - trityl - 1h - tetrazol 5 yl) diphenyl - 4 - yl) - 1.3 - diazaspiro - 4.4 - ninth - 4 - on

摘要

Provided is a novel method of making 2-butyl-3-[[2'(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.