C1-SYMMETRIC BISPHOSPHINLIGANDES AND THEIR USE IN THE ASYMMETRIC SYNTHESIS OF PREGABALIN

摘要

Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include CSUB1/SUB-symmetric bisphosphine ligands bound to transition metals.