PROCEDURES FOR THE DEFINITION OF CONNECTIONS WHICH MAKE THE PROPOSALS CARDIOVASCULAR

摘要

The invention relates to compositions and methods for screening molecules that are used for the prevention or treatment of metabolic syndrome, cardiovascular diseases and/or atherosclerosis. In particular, the invention relates to methods and kits for screening compounds based on determining the effect of test compounds on the activity of a novel protein which is similar to apolipoprotein AIV. The invention also relates to compositions and methods for reducing the concentration of triglycerides and/or reducing the concentration or the expression of apolipoprotein CIII (apo CIII) and/or reducing the concentration of VLDL and/or increasing the activity of LpL and/or of HL and/or for increasing reverse cholesterol transport.