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Expression and export technology of immuno globin bound to proteins as fusion proteins
Expression and export technology of immuno globin bound to proteins as fusion proteins
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机译:免疫球蛋白以融合蛋白的形式表达和输出技术
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摘要
Disclosed are DNAs produced by recombinant techniques for inducing the expression and subsequent secretion of a target protein. The DNAs encode, in their 5' to 3' direction, a secretion cassette, including a signal sequence and an immunoglobulin Fc region, and a target protein. The DNAs can be transfected into a host cell for the expression, production and subsequent secretion of the target protein as a fusion protein. The secreted protein can be collected from the extracellular space, and further purified as desired. The secreted fusion protein additionally can be proteolytically cleaved to release the target protein from the secretion cassette.
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