Use of skin penetration enhancers and agents for the enhancement of the upper skin layers suitable for increasing the transcutaneous immune response

摘要

Disclosed is a formulation comprising an antigen and an adjuvant for transcutancous immunization of a subject, wherein the antigen induces an immune response specific for the antigen following application of the formulation to the subject's unperforated skin which is treated to disrupt the stratum corneum.