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PAGE-4, A GAGE-SIMILAR GENE ON THE X-CHROMOSOME EXPRESSED BY NEOPLASTIC PROSTATE, TESTIS AND UTERUS, AND ITS APPLICATIONS
PAGE-4, A GAGE-SIMILAR GENE ON THE X-CHROMOSOME EXPRESSED BY NEOPLASTIC PROSTATE, TESTIS AND UTERUS, AND ITS APPLICATIONS
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机译:PAGE-4,一种由赘生性前列腺,睾丸和子宫表达的X-染色体上的类似基因的基因及其应用
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摘要
PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
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