Preparing deutrated potassium dihydrogen phosphate crystal, comprises producing crystalline solution with part of supersaturated solution of the compound, and continuous circulating solution between crystallization and saturation chambers

摘要

The process for preparing a potassium dihydrogen phosphate or deutrated potassium dihydrogen phosphate crystal (1), comprises producing a crystalline solution with a part of supersaturated solution of the compound, growing the crystal in a chamber maintained at 15-25[deg] C, making a continuous circulation of a solution to ultrasounds associated to heating or cooling of the solution between the crystallization and saturation chambers (10, 20) while maintaining a constant supersaturation (higher than 10%) in the crystallization chamber, and treating the solution. The process for preparing a potassium dihydrogen phosphate or deutrated potassium dihydrogen phosphate crystal (1), comprises producing a crystalline solution with a part of supersaturated solution of the compound, growing the crystal in a chamber maintained at 15-25[deg] C, making a continuous circulation of a solution to ultrasounds associated to heating or cooling of the solution between the crystallization and saturation chambers (10, 20) while maintaining a constant supersaturation (higher than 10%) in the crystallization chamber, and treating the solution to eliminate or inhibit the formation of aggregates. The crystallization chamber is in fluid communication with the saturation chamber having an excess of compound with a solid nourishing body and having a constant temperature. Solubility of the compound in the solution at saturation temperature is higher than solubility of the compound in the solution at crystallization temperature. The temperature difference between the saturation chamber and crystallization chamber is 2-30[deg] C. Independent claims are included for: (1) a deutrated potassium dihydrogen phosphate monocrystal; and (2) a device for preparing a deutrated potassium dihydrogen phosphate crystal.