Film, useful as drug to treat nausea, comprises water-soluble support containing active substance, where the support is obtained by mixing hydrophilic film forming agent and active substance with hydrophilic gelling agent in water

摘要

Film for rapid disintegration for oral administration of active substance, comprises a water-soluble support containing at least an active substance, where the support is obtained by mixing a hydrophilic film forming agent and an active substance with hydrophilic gelling agent in the presence of water to obtain a homogenous aqueous polymeric mixture, without exterior heat supply; and the proportion of the film forming and gelling agent is determined to confer the mixture, before the formation of film by classic technique of coating and drying. Film for rapid disintegration for oral administration of active substance, comprises a water-soluble support containing at least an active substance, where: the support is obtained by mixing a hydrophilic film forming agent having a viscosity of 1-250 mPa.s at ambient temperature and an active substance with hydrophilic gelling agent in the presence of water for obtaining a homogenous aqueous polymeric mixture, without exterior heat supply; and the proportion of the film forming agent and the gelling agent is determined for conferring the homogenous aqueous polymeric mixture having a viscosity of 250-15000 mPa.s, preferably 1500-9000 mPa.s at ambient temperature, before the formation of film by classic technique of coating and drying. An independent claim is included for a preparation of the film comprising dispersion of film constituents in water, mixing and homogenization of the dispersion and enduction and drying the mixture. ACTIVITY : Antiemetic. MECHANISM OF ACTION : None given. No biological data given.