METHOD AND COMPOSITION FOR PREDICTING DEATH BY CANCER AND SURVIVAL RATE OF PROSTATIC CANCER BY USING GENE EXPRESSION SIGNATURE

摘要

PPROBLEM TO BE SOLVED: To provide an improved method for predicting the clinical outcome of a diseased state such as cancer, etc. PSOLUTION: This emerging concept of cancerous stem cells suggests that the activation of "stemness" genetic pathways in transformed cells (e.g. the self renewal pathways of normal cells) may contribute to the survival life cycle of the cancer stem cells and the tumor progression and metastasis of malignancy. Thus, the activation of the "stemness" genes in cancer cells may be associated with the aggressive clinical behavior and increased likelihood of therapy failure. The general methods and kits associated with the prediction of clinical outcome for a diseased state of a subject based on gene expression analysis are described. The invention includes determining the expression of at least 3 genes selected from the group consisting of GBX2, MKI67, CCNB1, BUB1, KNTC2, USP22, HCFC1, RNF2, ANK3, FGFR2 and CES1, and their mouse homologs. PCOPYRIGHT: (C)2009,JPO&INPIT