METHOD FOR TREATING PSYCHOSIS ASSOCIATED WITH GLUCOCORTICOID-RELATED DYSFUNCTION

摘要

PPROBLEM TO BE SOLVED: To provide the methods and compositions for ameliorating pathologies or conditions associated with psychosis. PSOLUTION: This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in the methods for ameliorating pathologies or conditions associated with psychosis. These pathologies or conditions include psychotic major depression, schizoaffective disorders, Alzheimer's disease and cocaine addiction. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for remission of psychosis in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist. PCOPYRIGHT: (C)2009,JPO&INPIT