METHOD OF ELIMINATING BOMBYX MORI MACULA-LIKE LATENT VIRUS

摘要

PROBLEM TO BE SOLVED: To provide a method of eliminating or inactivating a Bombyx mori macula-like latent virus to increase virus safety on preparing a useful protein using a silkworm derived cell line, in view of a report that the Bombyx mori macula-like latent virus is present in many of silkworm derived cell lines, which cells are used in accumulating a useful protein in a culture medium or in the body of a silkworm.;SOLUTION: On preparing a useful protein using a silkworm derived cell line, a Bombyx mori macula-like latent virus contained in the cell can be eliminated by subjecting an intermediate product obtained in the protein-preparation process to a chromatography treatment.;COPYRIGHT: (C)2009,JPO&INPIT