METHOD OF PREPARATION OF OPTICALLY-ACTIVE 4-HALO-3-HYDROXYBUTYLAMIDE AND OPTICALLY-ACTIVE 4-HALO-3-HYDROXY BUTYRONITRILE AS WELL AS OPTICALLY ACTIVE CARNITINE AMIDE

摘要

PROBLEM TO BE SOLVED: To provide a method of preparation of optically-active 4-Halo-3-hydroxybutylamide and its precursor as well as its derivative which are highly-productive and are favorable in terms of costs and environmental point of view.;SOLUTION: The method of preparation of the optically-active 4-Halo-3-hydroxybutylamide includes: a process (1) for obtaining optically-active 4-Halo-3-hydroxy butyronitrile by an enzyme reaction by halohydrin epoxydase; a process (2) in which the reaction liquid obtained in the process (1) is distilled and concentrated for separating unreacted materials; a process (3) in which the residue of the process (2) is subjected to heating treatment and/or addition treatment of metal sa and a process (4) in which nitrile-hydratase is added to the process liquid obtained by the process (3) under specific conditions. The method of preparation of the precursor includes the above processes (1) and (2). Also, the method of preparation of the derivative employs the optically-active 4-Halo-3-hydroxybutylamide.;COPYRIGHT: (C)2009,JPO&INPIT