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Human mutator gene hMSH2 and hereditary nonpolyposis colorectal cancer
Human mutator gene hMSH2 and hereditary nonpolyposis colorectal cancer
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机译:人类突变基因hMSH2与遗传性非息肉性结直肠癌
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摘要
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error+ (RER+) tumor cells.
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