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Dividing method of the racemic mixtures, as well as diastereoisomers enantiomers of interest and a resolving agent

机译:外消旋混合物以及目标非对映异构体对映异构体和拆分剂的划分方法

摘要

A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c) separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.
机译:描述了一种外消旋形式的化合物的拆分方法,包括以下步骤:a)使外消旋形式的化合物与拆分剂反应,b)形成拆分剂和目标对映异构体的非对映异构体复合物,c)分离对映异构体该方法的特征在于,所述拆分剂是式(I)的化合物。还描述了式(I)的拆分剂与目的对映异构体之间的非对映异构体复合物。根据本发明的方法允许分离酸和碱性外消旋混合物。

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