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Targeted gene delivery to non-phagocytic mammalian cells via intact minicells from bacteria
Targeted gene delivery to non-phagocytic mammalian cells via intact minicells from bacteria
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机译:通过细菌中完整的小细胞靶向基因递送至非吞噬性哺乳动物细胞
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摘要
A method of targeting bacterially-derived, intact minicells to specific, non-phagocytic mammalian cells employs bispecific ligands to deliver nucleic acids efficiently to the mammalian cells. Bispecific ligands, comprising (i) a first arm that carries specificity for a bacterially-derived minicel surface structure and (ii) a second arm that carries specificity for a non-phagocytic mammalian cell surface receptor are useful for targeting minicells to specific, non-phagocytic mammalian cells and causing endocytosis of minicells by non-phagocytic cells.
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