Solution and method for resuscitation and compensation of ischemic injury tissue

摘要

The invention discloses a process and resuscitation solution for inducing repair of ischemically damaged organs and tissues, to the degree that impairment of function can be reversed; and preventing further tissue damage during restoration of the circulation of the treated organ or tissue. The process comprises flushing the organ with the resuscitation solution according to the present invention at a warm temperature of about 28 DEG C. to about 37 DEG C. to remove accumulated blood and acidotic products from blood flow deprivation; and perfusing the flushed organ or tissue with the resuscitation solution, wherein the solution contains a novel combination of components to provide for (i) dilating of the blood vessels within the organ or tissue, (ii) reestablishing organ or tissue function by supplying trophic factors, (iii) restoring cellular integrity and function to the ischemically damaged organ or tissue, and (iv) reestablishing oxidative metabolism by readapting the ischemically damaged organ or tissue, surviving by anaerobic respiration, to an oxygenated resuscitation solution.