Short-chain deoxyribonucleic acid or sustained-release microspheres containing short-chain ribonucleic acid and method for producing the same

摘要

In a sustained-release microsphere preparation comprising a short-chain deoxyribonucleic acid or a short-chain ribonucleic acid as an active ingredient, the sustained-release property is improved and a preparation effective for a long period of time is provided. An injectable or transmucosally administrable fine particle formulation in which short-chain deoxyribonucleic acid or short-chain ribonucleic acid is stably encapsulated and the expression of a specific protein involved in a disease can be suppressed over a long period of time, and a method for producing the same provide. In biodegradable polymers in sustained-release microsphere preparations containing short-chain deoxyribonucleic acid or short-chain ribonucleic acid, especially siRNA as active ingredients, especially sustained-release microspheres prepared via w1 / o / w2 emulsion It contains a basic substance having a positive charge such as arginine, polyethyleneimine, cell-penetrating peptide, poly-L-lysine, poly-L-ornithine.