首页> 外国专利> 4 '-{2-(1S, 2R) -2-hydroxy-2- (4-hydroxyphenyl) -1-methylethylamino ethoxy} -3-isopropyl-3', 5'-dimethylbiphenylcarboxylic acid Polymorph of salt

4 '-{2-(1S, 2R) -2-hydroxy-2- (4-hydroxyphenyl) -1-methylethylamino ethoxy} -3-isopropyl-3', 5'-dimethylbiphenylcarboxylic acid Polymorph of salt

机译:4'-{2-[((1S,2R))-2-羟基-2-(4-羟基苯基)-1-甲基乙基氨基]乙氧基} -3-异丙基-3',5'-二甲基联苯羧酸盐的多晶型物

摘要

Of 4 ′-{2-[(1S, 2R) -2-hydroxy-2- (4-hydroxyphenyl) -1-methylethylamino] ethoxy} -3-isopropyl-3 ′, 5′-dimethylbiphenylcarboxylic acid Provided are α-form, β-form and γ-form crystals that can be distinguished by a characteristic diffraction peak of powder X-ray diffraction produced by treating hydrochloride with a specific solvent. The crystals according to the present invention, particularly the α-form, β-form and γ-form crystals, have no problem of residual solvent and are excellent in stability during storage.
机译:由4'-{2-[(1S,2R)-2-羟基-2-(4-羟基苯基)-1-甲基乙基氨基]乙氧基} -3-异丙基-3',5'-二甲基联苯羧酸提供,β-型和γ-型晶体可以通过用特定溶剂处理盐酸盐产生的粉末X射线衍射的特征衍射峰来区分。根据本发明的晶体,特别是α型,β型和γ型晶体,没有残留溶剂的问题,并且在储存期间的稳定性优异。

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