The method where it can execute safety medicine reason test respiratory system medicine reason test of the large animal of specification, conversion being easy, be able to lighten the influence of stress, vis-a-vis the respiratory system medicine reason test system, the chamber device, and the identical individual large animal which at the same time can be executed in non anesthesia and nonrestraint state is offered. The chamber device of this invention, the cage has with 10 for the animal and transparent chamber 20, the said chamber 20, 1st division 21 and, has with 2nd division 22, both divisions are divided by partition plate 23. Division 21, has the door and the connected mouth 26, for ventilation division (21,22), has the communication tube 29 which possesses opening 29a which introduces the air. The device of this invention in a state where the cage 10 is accommodated in division 21, keeps the flow of the air which is while the said dividing uniformly, in order to circulate the air even inside cage 10, connected mouth 26 for ventilation provides the communication tube 29 which introduces the air into the side of chamber 20, in the surface of chamber 20.
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