Process for the preparation of Retapamulin and its intermediates

摘要

Processes for preparing tropine derivatives of the following Formula B; ;are provided where LG represents a leaving group. The tropine derivatives may be used to prepare Retapamulin, preferably in substantially pure form. Also provided are processes for preparing Retapamulin comprising combining a base, tropine thiol in a free base or salt form, an organic solvent, and a pleuromutilin derivative of Formula A:;