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Homoeologous Region Determining Method by Homo Junction Fingerprint Method, Homoeologous Region Determining Device, and Gene Screening Method

机译:同源连接指纹法的同源区域确定方法,同源区域确定装置和基因筛选方法

摘要

To provide a method for efficiently searching for a recessive disease gene without needing any pedigree analysis. In a homoeologous region determining method, the following steps are conducted. It is determined whether or not the base constituting a polymorphic marker of a sample DNA of diploid or higher polyploidy is a homojunction. Homojunction region information representing the region of the sample DNA where polymorphic markers determined as continuous homojunctions acquired. If the continuous probability and/or continuous distance of the polymorphic markers contained in the homojunction region information satisfy a predetermined determination condition, the homojunction region is determined as a homoeologous region. A homoeologous region determining device and a gene screening method for identifying a disease susceptibility gene from the determined homoeologous region are also provided.
机译:提供一种无需任何谱系分析即可有效搜索隐性疾病基因的方法。在同源区域确定方法中,执行以下步骤。确定构成二倍体或更高倍性的样品DNA的多态性标记的碱基是否为同质结。同质结区域信息代表样品DNA的区域,在该区域中获取了确定为连续同质结的多态性标记。如果包含在同质结区域信息中的多态性标记的连续概率和/或连续距离满足预定的确定条件,则将该同质结区域确定为同源区域。还提供了用于从所确定的同源区域中识别疾病易感基因的同源区域确定装置和基因筛选方法。

著录项

  • 公开/公告号US2009155782A1

    专利类型

  • 公开/公告日2009-06-18

    原文格式PDF

  • 申请/专利权人 KOICHI HAGIWARA;

    申请/专利号US20060988812

  • 发明设计人 KOICHI HAGIWARA;

    申请日2006-07-07

  • 分类号C12Q1/68;C12M1/34;

  • 国家 US

  • 入库时间 2022-08-21 19:36:28

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