Characterization of a MEKK binding site and uses thereof

摘要

The present invention provides binding motifs, binding sites, peptides, and 14-3-3/MEKK complexes. Also provided are agents reactive with same, pharmaceutical compositions, molecules, and kits comprising same, and methods of producing same. The present invention further provides isolated nucleic acids and constructs comprising same, host cells comprising the constructs, and transgenic non-human animals. Additionally, the present invention provides methods of: (a) facilitating or inhibiting 14-3-3/MEKK interaction, (b) regulating MEKK activity, (c) identifying agents that interact with MEKK or 14-3-3, (d) detecting and monitoring the development of MEKK-mediated conditions, and (e) treating and/or preventing MEKK-mediated conditions.