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Hybrid Biomedical Device Fabricated From Biomaterials and Coated With a Natural Extra Cellular Matrix (ECM) Coating
Hybrid Biomedical Device Fabricated From Biomaterials and Coated With a Natural Extra Cellular Matrix (ECM) Coating
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机译:由生物材料制成并涂有天然细胞外基质(ECM)涂层的混合生物医学设备
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摘要
The present invention relates to a hybrid biomedical device formed from a prefabricated biomedical device and coated with an extracellular matrix coating which is produced by directly culturing mammalian cells on the prefabricated biomedical device. The purposes of applying such an ECM coating is to regulate the biological and cellular responses of a living tissue or a cellular environment that the hybrid biomedical device is intended to interact with. The ECM coating will provide necessary biological cues, biomechanical cues, structural cues, etc to regulate the biological and cellular responses of a living system. The invention further provides methods of making the hybrid biomedical device.
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