Non-Invasive Total Hemoglobin Measurement by Spectral Optical Coherence Tomography

摘要

Spectral Optical Coherence Tomography (“SOCT”) utilizes Optical Coherence Tomography (“OCT”) to depth-target two or more optical measurements within a blood vessel. OCT achieves depth resolution by the use of optical interferometry. As the path length of the reference arm of the interferometer is varied, the penetration depth at which maximum interference occurs (zero phase difference) in the sample is correspondingly increased. Depth resolution in the range of 10 μm to 100 μm enables measurements that may be made within more narrow spectral regions (in the range of 1 to 50 nm) in multiple regions of the visible and near infrared spectrum. In one embodiment the light source is configured for three spectral regions centered at 805 nm, 980 nm, and 1050 nm. By comparing the OCT signal at these different spectral positions, the absorption due to tissue and blood analytes may be measured.