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Pre-B Cell Proliferation and Lymphoblastic Leukemia/High-Grade Lymphoma in MIR155 Transgenic Mice
Pre-B Cell Proliferation and Lymphoblastic Leukemia/High-Grade Lymphoma in MIR155 Transgenic Mice
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机译:MIR155转基因小鼠的前B细胞增殖和淋巴细胞白血病/高级别淋巴瘤
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摘要
A transgenic non-human animal, such as a mouse, has a genome that include a nucleic acid construct having at least one transcriptional regulatory sequence capable of directing expression in B cells of the animal, wherein the transcriptional regulatory sequence is operably linked to a nucleic acid encoding a miR155 gene product. A method of testing the therapeutic efficacy of an agent in treating or preventing a lymphoproliferative condition includes assessing the effect(s) of the agent on a transgenic non-human animal.
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