首页>
外国专利>
Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds
Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds
展开▼
机译:仲酰胺肽化合物的顺/反异构化催化
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.
展开▼