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Novel TNF receptor death domain ligand proteins and inhibitors of ligand binding
Novel TNF receptor death domain ligand proteins and inhibitors of ligand binding
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机译:新的TNF受体死亡域配体蛋白和配体结合抑制剂
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摘要
Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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