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Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes
Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes
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机译:分离独特的脑膜炎奈瑟氏球菌血清群B表位的分子模拟物的方法
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摘要
Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique epitopes found on MenB or E. coli K1. Examples of such peptide mimetics are described that elicit serum antibody capable of activating complement-mediated bacteriolysis of MenB. Vaccine compositions containing such mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody.
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