Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it

摘要

The present invention provides a recombinant virus, which highly expresses a cancer therapeutic gene and specifically proliferates in tumor cells, and a method for the proliferation of the same. In said recombinant virus, the transcription of at least one VPEG is under the control of a hTERT promoter, whereby the virus selectively proliferates in telomerase activity positive tumor cells, but substantially not in normal cells negative in the telomerase activity. Said recombinant virus further contains a cancer therapeutic gene inserted in its genome, whereby the cancer therapeutic gene is highly expressed in tumor cells. The tumor cells are killed by the synergistic effects of the virus and the cancer therapeutic gene. Such recombinant viruses can be used to treat various tumors.