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Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
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机译:制备改良的布鲁氏菌 i>菌株质粒以开发菌株的方法以及包含所述菌株的疫苗
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摘要
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live vaccine for immunization, prophylaxis or treatment of brucellosis comprises such a bacterium, either lyophilized or in a pharmaceutical vehicle. Nucleotide sequence fragments having the aforementioned deletion are disclosed, with methods for making them.
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