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Methods for inhibition of membrane-fusion-associated events, including Hepatitis B virus transmission
Methods for inhibition of membrane-fusion-associated events, including Hepatitis B virus transmission
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机译:抑制膜融合相关事件包括乙型肝炎病毒传播的方法
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摘要
The present invention relates to peptides which exhibit potent anti-viral activity. In particular, the invention relates to methods of using such peptides as inhibitory of hepatitis B virus (“HepB”) transmission to uninfected cells. The peptides used in the methods of the invention are homologs of the DP-178 and DP-107 peptides, peptides corresponding to amino acid residues 638 to 673, and to amino acid residues 558 to 595, respectively, of the HIV-1LAI transmembrane protein (TM) gp41.
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机译:本发明涉及表现出有效抗病毒活性的肽。特别地,本发明涉及使用这样的肽作为抑制乙型肝炎病毒(“ HepB”)向未感染细胞的传播的方法。本发明方法中使用的肽是DP-178和DP-107肽的同源物,分别对应于HIV-1 LAI Sub>跨膜蛋白(TM)gp41。
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