Condensation Reduction Methods in a single container to prepare substituted allylic alcohols, processes to obtain a quinolone Derivative of 4 - and for the separation of isomeric alcohols and other compounds

摘要

Condensation Reduction methods are provided in a single container to prepare substituted Allyl alcohols as well as highly Selective extraction methods to separate isomeric alcohols produced in processes of condensation reduction in a single container to prepare for and Example, a quinolone.Claim 1: a method to prepare one or more compounds of formula (1), where R1 and R2 are independently selected from h, aryl, alquiloc1 alqueniloc2 - 10, - 10 and - 10 or alquiniloc3, R1, R2, and the C Atom which can be joined together cicloalquiloc3 - 10 or heterociclilo; and R3 is Alquiloc1 alqueniloc2 h, - 10, - 10, - 10 alquiniloc3, halogen, aryl, heteroaryl or heterociclilo,Said method comprises (a) REACT in the presence of one or more bases, one or more compounds of formula R1R2 (= OR) where R1 and R2 are independently selected from aryl, alquiloc1 h, - 10, - 10 and - 10 alqueniloc2 alquiniloc3 or R1, R2 and the C Atom to which Unite together can form CIC Loalquiloc3 - 10 or heterociclilo, with a compound of formula (2) where R3 is selected from h,Alquiloc1 alqueniloc2 - 10 - 10, 10, alquiniloc3, halogen, aryl, heteroaryl, and heterociclilo, R5, R6 and R7 is independently selected from - 10 alquiloc1 and aryl; and (b) one or more additional reducing agents in the reaction of the step (a).Claim 1: a method to separate isomeric alcohols of formula (1) in a Watery mixture where R1 and R2 are different groups selected from h, alquiloc1 alqueniloc2 - 10, - 10 and - 10 or alquiniloc3, R1, R2, and the C Atom to bind together a group can be Asymmetric. Cicloalquiloc3 held between - 10 and heterociclilo replaced optionally substituted; R3 is H,Alquiloc1 - 10 not replaced, halogen, aryl, or heterociclilo, Said method comprises (a) contacting an aqueous mixture of isomeric alcohols with an appropriate volume of a non polar Solvent; and (b) Separating non polar Solvent from the aqueous layer.Claim: a method for Separating isomers of formula (3) in a solution of n-butanol where R1, R2 and the C Atom which bind together form (4); R3 is not alquiloc1 - 10 h, halogen substituted aryl, or heterociclilo; and N is 0 - 4Said method comprises (a) contacting an aqueous mixture of isomer of formula (3) with an appropriate volume of a mixture of HCl and IPA; (b) heating the resulting solution to a temperature between about 85 degrees Celsius and approximately 118u00b0C; and (c) add IPA in the resulting Solution.