Compounds for the treatment of Sexual Dysfunction of mu opioid receptor Selective antagonist. Use. Pharmaceutical composition

摘要

Procedures for the treatment of Female Sexual Dysfunction with an antagonist Selective for the mu opioid receptors. It also describes Combination Treatments with other classes of agents.Claim 1: Use of a selective antagonist of mu opioid receptors is characterized in that in the preparation of a Medicament for the Prevention and / or treatment of Female Sexual Dysfunction (DSF). Claim 1: Use according to claim 17, wherein the compound is Mesylate Exo - N - {3 - [6 - (ethyl - 2 - hydroxy - 3 - methyl - 2 - indan) - 3 - aza Bicyclo [3.1.Hex - il - 6 0]}] - phenyl - methanesulfonamide.Claim 1: use an antagonist Selective for the mu opioid receptors together with an Auxiliary Agent wherein is selected from one or more of: (i) compounds that modulate the action of natriuretic factors.In particular the atrial natriuretic factor; (ii) compounds that inhibit angiotensin converting Enzyme; (iii) no synthase Substrates; (iv) cholesterol lowering agents; (V) modulators of the estrogen Receptors and estrogen agonists / antagonists of estrogen and / or INH; (VI) Ibidores of phosphodiesterase (PDE); (vii) vasoactive intestinal Protein (IVP), Mimetic of IVP,Analogue of IVP, a receptor agonist of IVP or Fragment of IVP or a combination of an antagonist of adrenoceptors with PIV; (viii) agonist, antagonist of the serotonin receptor modulators or agents; (IX) replacement of testosterone or testosterone implants; X) Selective Androgen receptor modulators of estrogen, XI);Estrogens and medroxyprogesterone or medroxyprogesterone acetate (MPA) (i.e., in the form of Combination) or estrogen and hormone replacement treatment agent of methyltestosterone; (XII) or progesterone, progesterone agonist modulators such as gestodine, ethinyl estradiol, ethynodiol, Etonogesterol Implant, dihidrogesterona, progesterone, totelle sekvens,Norethynodrel or progesterone Creams or gels such as muprogest, natragest and FEM - gest; XIII) modulators of conveyors for noradrenaline.Dopamine and serotonin and / or; (XIV) agonists or modulators of the oxytocin / vasopressin receptor agonists); 15th or 16th Melanocortin Receptor modulators; inhibitors of monoamine Transport); (XVII) dopamine agonists (in particular Selective agents Selective D2, D3,Selective D2 and D4 selective); XVIII) Alpha adrenergic Receptor Antagonists (also known as Alpha adrenoceptor blockers, Alpha blockers, or Receptor Blockers)Anti diabetic agents; XIX and XX) receptor modulators (NPY agonists and / or antagonists) in the preparation of a Medicament for the Prevention and / or treatment of Female Sexual Dysfunction.Claim 1: a Pharmaceutical composition which comprises a selective antagonist of mu opioid Receptors and one or more Auxiliary agents selected from: (i) compounds that modulate the action of natriuretic factors.In particular the atrial natriuretic factor; (ii) compounds that inhibit angiotensin converting Enzyme; (iii) no synthase Substrates; (iv) cholesterol lowering agents; (V) modulators of the estrogen Receptors and estrogen agonists / antagonists of estrogen and / or INH; (VI) Ibidores of phosphodiesterase (PDE); VII (IVP), vasoactive intestinal Protein Mimetic of IVP,Analogue of IVP, a receptor agonist of IVP or Fragment of IVP or a combination of an antagonist of adrenoceptors with PIV; viii) agonists, antagonists and modulators of serotonin receptors; (IX) replacement agents of testosterone or testosterone implants; X Selective Androgen receptor modulators); (XI) estrogenEstrogens and medroxyprogesterone or medroxyprogesterone acetate (MPA) (i.e., in the form of Combination) or estrogen and hormone replacement Treatment agents of methyltestosterone; (XII) or progesterone, progesterone agonist modulators such as gestodine, ethinyl estradiol, ethynodiol, Etonogesterol Implant, dihidrogesterona, progesterone, totelle sekvens,Norethynodrel or progesterone Creams or gels such as muprogest, natragest and FEM - gest; XIII) modulators of conveyors for noradrenaline.Dopamine and serotonin and / or; (XIV) agonists or modulators of the oxytocin / vasopressin receptor agonists); 15th or 16th Melanocortin Receptor modulators; inhibitors of monoamine Transport); (XVII) dopamine agonists (in particular Selective agents Selective D2, D3,Selective D2 and D4 selective); XVIII) Alpha adrenergic Receptor Antagonists (also known as Alpha adrenoceptor blockers, Alpha blockers or Receptor Blockers), anti diabetic agents; XIX) and (XX) modulators of NPY Receptor agonists and / or antagonist ( As).Claim 21: A Selective antagonist of mu opioid receptors because is characterized for use in the Prevention and / or treatment of Female Sexual Dysfunction (DSF).