Piridopirimidinona AZA Derivatives, method of preparation, medicines containing them and uses as antithrombotic agents, Antidiabetic and antihyperlipidemic, among others.

摘要

These compounds are resistant to hm74a and can be used as drugs. Claim 1: formula compound (1), wherein X1 is n or C (R6);X2 is n or C (R7);X3 is n or C (R8)There, at least one x1, X2 and X3 is n, and one can, O, n (R9) C (o),C (O) NR9 N (R9) C (O) O OC (O) NR9 N (R9) C (O) NR10 N (R9) SO2 o SO2N (R9)Z is a simple bond, or, if n is 1, 2, 3, 4, 5 or 6, it can also be o; R1, R2, R3 and R4, whether hydrogen, fluorine, hydrocarbyl or fluoride of lower hydrocarbyl, or R1 and R2, are all combined to form a carbon atom connected with it and - r1-r2-es (CH2) 2-6 -.R3 and R4 are combined to form a ring with the carbon atoms they are connected to, and - r3-r4-es - (CH2) 2-6 -;R5 is arilo or heteromorphic, arilo or heteromorphic substitutes are 1 to 3 independent substitutes, including halogen, tar, low oxygen, low fluoride tar, low fluoride oxygen, low fluoride oxygen, cyclopentyl, fluorine cyclopentyl, cyclopentyl oxygen, C (o) Oh, low oxygen-c (o),this is it!N (h, lower bitumen) C (o),N (lower) 2C (o),Oh, lower tar - C (o) or, NH2, n (h, lower tar),N (lower pitch) 2, lower pitch-c (o) NH, lower pitch-c (o) n,NH2SO2, N (H, lower alkyl) SO2, N (lower alkyl) 2SO2, lower alkyl-SO2-NH, lower alkyl-SO2-N (lower alkyl),cyano and phenyl which is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, lower alkyl, lower alkoxy and fluor-lower alkyl; R6 is hydrogen, halogen, lower alkyl, fluor-lower alkyl, lower alkoxy, fluor-lower alkoxy or cycloalkyl; R7 is hydrogen, halogen, lower alkyl, fluor-lower alkyl, lower alkoxy, fluor-lower alkoxy or cycloalkyl; R8 is hydrogen, halogen, lower alkyl, fluor-lower alkyl, lower alkoxy, fluor-lower alkoxy or cycloalkyl; R9 and R10 independently of each other are hydrogen, lower alkyl or fluor-lower alkyl; m is 0, 1,N is 0, 1, 2, 3, 4, 5, 6; m + n is = 1; but the condition is that if X1 is ch, X2 is ch, X3 is n, M + n is not 1; and salt and ester that can be accepted from drug.