首页>
外国专利>
A modified release dosage form of Tacrolimus and a method for Preparation of modified release dosage form of Tacrolimus
A modified release dosage form of Tacrolimus and a method for Preparation of modified release dosage form of Tacrolimus
展开▼
机译:他克莫司的缓释剂型及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Modified release dosage form of tacrolimus that releases two or more quantities of tacrolimus after oral administration, the first amount of tacrolimus is released from the Dosing Unit inmediatasubstancialmente Release immediately within the 0 - 2 hoursFollowed by a time interval ranging from approximately 1 to 10 hours during which substantially no amount of tacrolimus is released from the dosage form, after releasing a Second amount of tacrolimus in where the second amount is released from the unit Delayed release dosage either immediately, for example: The 0 - 2 hoursOr a period of time which varies approximately 2 - 12 hours since the initial release of the Dosing Unit delayed release. The dosage form may also include an additional amount of tacrolimus to provide additional pulses of tacrolimus.Tacrolimus dosage forms Exhibit improved bioavailability and reduced Flow or fluctuation on the compositions of tacrolimus. Also described is a method for preparing the dosage forms.
展开▼