polypeptide, dna sequence, dna vector, antibody, bacterium, method for producing partially 3-o-deacylated lps, composition, uses of the bacterium, and isolated bordetella lps comprising at least partially 3-o-deacylated lps, vaccine, and, in vitro method for deacylating gram-negative lps or compositions comprising gram-negative lps.

摘要

Polypeptide, DNA Sequence, DNA VECTOR, ANTIBODY, BACTERIA, METHOD FOR PRODUCING PARTIALLY 3-O-DISABLED LPS, COMPOSITION, USES OF BACTERIA, AND LPS OF BORDETELLA ISOLATED COMPLETE LACIN-LPS PLATE AND, IN VITRO METHOD FOR DISABILING GRAM NEGATIVE LPS OR COMPOSITIONS UNDERSTANDING GRAM NEGATIVE LPS. The present invention provides novel Gram-negative polypeptides exhibiting 3-O-deacylase lipid A activity and which are capable of modifying and / or detoxifying Gram-negative LPS. The present invention also provides Gram-negative bacteria, Gram-negative lipopolysaccharide (LPS) bacteria, and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and / or veterinary purposes, in particular for the preparation of acellular or whole cell vaccines against Gram-negative pathogens such as Bordeteila pertussis, Bordeteila parapertussis, and Bordetelia bronchiseptica.