use of a benzodiazepine or a pharmaceutically acceptable salt thereof, method for treating or preventing an hcv infection in a patient, benzodiazepine derivative or a pharmaceutically acceptable salt thereof, and pharmaceutical composition

摘要

USE OF A BENZODIAZEPIN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD TO TREAT OR PREVENT HCV INFECTION IN A PATIENT, BENZODIAZEPIN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE COMPOSITION. The use of a benzodiazepine of formula (1), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment or prevention of a hepatitis C infection, wherein: R represents C 1-6 alkyl aryl or heteroaryl; R 2 represents hydrogen or C 1-6 alkyl; each R is the same or different and represents halogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 thioalkyl, C 1-6 haloalkyl, C 1-1 haloalkoxy -6-, amino, mono (C1-6 alkyl) amino, di (C1-6 alkyl) amino, nitro, cyano, -CO2-2 R ', -CONR'R ", -NH -CO-R ', S (O) R', -S (O) -2-R ', -NH-S (O) -2-R', -S (O) NR'R "or. -S (O) ~ 2-NR'R "where each R 'and R" is the same or different and represents hydrogen or C 1-6 alkyl; - n is from 0 to 3; - represents hydrogen or C 1-6 alkyl; - R5-5 represents C1-6 alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl (C1-6 alkyl) -, heteroaryl (C1-6 alkyl) -, carbocyclyl ( C 1-6 ~ - heterocyclyl (C 1-6 alkyl), aryl (C 1-6 hydroxyalkyl), heteroaryl (C 1-6 hydroxyalkyl), carbocyclyl (C 1-6 hydroxyalkyl) -1-6-) -, heterocyclyl- (C 1-6 hydroxyalkyl) -, aryl-C (O) -C (O) -, heteroaryl-C (O) -C (O) - carbocyclyl-C (O) -C (O) -, heterocyclyl-C (O) -C (O) - or -XR; X represents -CO-, -S (O) - or -S (O) -2 -; and R 6 'represents C 1-6 alkyl, hydroxy, C 1-6 alkoxy, C 1-6 thioalkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl (C 1-6 alkyl) ) -, heteroaryl - (C 1-6 alkyl) -, carbocyclyl (C 1-6 alkyl) -, heterocyclyl (C 1-6 alkyl) -, aryl (C 1-6 alkyl) ~) - O-, heteroaryl (C 1-6 alkyl) -O-, carbocyclyl (C 1-6 alkyl) -O-, heterocyclyl (C 1-6 alkyl) -O- or -NTR'R "where each R 'and R" is the same or different and represents hydrogen, C 1-6 alkyl, carbocyclyl, heterocyclyl, aryl, het eroaryl, aryl- (C 1-6 ~ heteroaryl - (C 1-6 earbocyclyl - (C 1-6 alkyl)) or heterocyclyl (C 1-6 alkyl)