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Use of compounds with biological activity of vasoactive intestinal peptide for the treatment of sarcoidosis

机译:具有血管活性肠肽生物学活性的化合物在结节病治疗中的用途

摘要

The present invention relates to peptides which arm highly biologically and pharmacologically active as therapeutic drug for the treatment of diseases related to sarcoidosis. The peptides which can be used according to the invention for the treatment of said disease comprise at least one specific highly conservative amino acid residue sequence which seem to play an important role in connection with pulmonary and arteriolar hypertension events. It could be shown that the known naturally occurring peptides "vasoactive intestinal peptide (VIP)" and "pituitary adenylate cyclase-activating polypeptide (PACAP)", having these specific sequences are potent drugs which can be successfully used for treatment of sarcoidosis. Furthermore, the present invention discloses a method for the treatment patients suffering from sarcoidosis.
机译:本发明涉及在生物学上和药理学上具有高度活性的肽,作为治疗与结节病有关的疾病的治疗药物。根据本发明可用于治疗所述疾病的肽包含至少一种特定的高度保守的氨基酸残基序列,该序列在肺和小动脉高血压事件中似乎起着重要的作用。可以证明具有这些特定序列的已知的天然存在的肽“血管活性肠肽(VIP)”和“垂体腺苷酸环化酶激活多肽(PACAP)”是有效的药物,可以成功地用于治疗结节病。此外,本发明公开了一种治疗结节病患者的方法。

著录项

  • 公开/公告号DK1515745T3

    专利类型

  • 公开/公告日2009-07-13

    原文格式PDF

  • 申请/专利权人 MONDOBIOTECH AG;

    申请/专利号DK20030722171T

  • 发明设计人 BEVEC DORIAN;

    申请日2003-06-05

  • 分类号A61K38;A61K38/22;A61P11;A61P35;A61P43;C07K7/06;C07K7/08;C07K14;

  • 国家 DK

  • 入库时间 2022-08-21 19:28:13

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