HUMAN MONOCLONAL ANTIBODIES TO PROTEINTHYROSINKINASE 7 (PTK7) AND METHODS OF APPLICATION OF ANTIBODIES AGAINST PTK7

摘要

The present invention includes isolated monoclonal antibodies, in particular human monoclonal antibodies that specifically bind to PTK7 with high affinity. Also provided are nucleotide molecules encoding the antibodies of the invention, expression vectors, host cells, and methods for expressing antibodies of the invention. Immunoconjugates, bispecific molecules, and pharmaceutical compositions containing antibodies of the invention are also encompassed. The invention also includes methods for detecting PTK7 and methods for treating various diseases, including cancer and infectious diseases, using antibodies against PTK7.