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摘要

The invention describes 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indo l-2-ones of formula (I): the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, Ris hydrogen or cyano; X is NR; Ris hydrogen or Calkyl; -a=a-a=a- represents a bivalent radical of formula CH=CH-CH=CH- (c-1);, where one of hydrogen atoms in the (c-1) radical can be replaced with Calkoxy or hydroxy; Ris furyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, benzofuryl, isobenzofuryl, etc benzothienyl, isobenzothienyl, indolyl, benzoxazolyl, benzimidazolyl, optionally substituted with one, two, or three substituents each independently selected from halo, cyano, nitro, Calkyl, CF. COOR, (R) (R)N-carbonyl, hydroxy, C)alkyloxy, (R) (R)N-, Calkylthio, Calkylsulfonyl; each Ris independently hydrogen, Calkyl, aryl Calkyl; each R, Ris independently hydrogen, Calkyl or aryl Calkyl. The compounds can be used as anti-infectious agents.