DERIVATIVES OF 4-(BENZYL)PIPERAZINE CARBOXYLIC ACID PHENYLAMIDE AND ASSOCIATED COMPOUNDS AS FATTY ACID AMIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER DISORDERS

摘要

Compounds of formula (I) : wherein, Z is -N-orCH; Ris -H or Calkyl; Aris 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-primidinyl, 5-pyrimidinyl, each unsubstituted or substituted at a carbon ring member with one or two Rmoieties; where each Rmoiety is independently selected from the group consisting of Calkyl, -Calkenyl, -OH, -OCalkyl, halo, -CF, -OCF, -SCF, -SH, -S(O)Calkyl, -OSOCalkyl, -COCalkyl, -COH, -COCalkyl, -N(R)R, -SONRR, -NRSOR, -C(=O)NRR, -NO, and -CN, wherein Rand Rare each independently -H or Calkyl; and Aris defined in the claims are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).