oral pharmaceutical formulation containing opioidagonisti vabanevas form and its manufacture opioidantagonisti allocated, the method and its use in medicine

摘要

Disclosed is an opioid antagonist composition and an oral dosage form comprising an opioid antagonist particle in a coating which is insoluble in the gastrointestinal system or an opioid antagonist dispersed in a matrix that renders the antagonist substantially non-releasable or an opioid antagonist dispersed in a melt-extruded matrix.