COMPOSITIONS, METHODS AND KITS FOR THE DIAGNOSIS CARRIERS OF MUTATION IN THE BRCA1 AND BRCA2 GENES AND EARLY DIAGNOSIS OF CANCEROUS DISORDERS ASSOCIATED WITH MUTATIONS IN BRCA1 AND BRCA2 GENS

摘要

The present invention relates to diagnostic compositions methods and kits for the detection of carriers of mutations in the BRCA1 and BRCA2 genes. The detection is based on the use of at least one detecting nucleic acid or amino acid based molecule, specific for determination of the expression of at least one marker gene of the invention, in a test sample. The invention thereby provides methods compositions and kits for the diagnosis of cancerous disorders associated with mutations in the BRCA1 and BRCA2 genes, specifically, of ovarian and breast cancer.