USE OF CHEMOKINE MUTANTS IN PREPARATION OF A COMPOSITION FOR TREATING MULTIPLE SCLEROSIS, SOME SUCH NEW MUTANTS AND THEIR PREPARATION

摘要

Mutants of CC chemokines, which contain at least two mutations in the cationic site of the 40's loop and which, relative to the wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective in the treatment of multiple sclerosis and/or other demyelinating diseases. A triple mutant of RANTES is the compound showing the best results.