SUBSTITUTED 2 - PYRIMIDINYL - 6,7,8,9 - TETRAHYDROPYRIMIDO {1,2-A} PYRIMIDIN - 4 - ONE AND 7 -PYRIMIDINYL - 2,3 - DIHYDROIMIDAZO {1,2-A} PYRIMIDIN - 5 (1H) ONE DERIVATIVES FOR NEURODEGENERATIVE DISORDERS

摘要

The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof as therapeutic agents: Wherein m, n, p, X, Y, R1, R2, R3, R4 R5, are as defined herein. The invention specifically relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 or GSK3 and cdk5/p25, such as Alzheimer disease.