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SPECIFIC AMPLIFICATION OF FETAL DNA SEQUENCES FROM A MIXED, FETAL-MATERNAL SOURCE
SPECIFIC AMPLIFICATION OF FETAL DNA SEQUENCES FROM A MIXED, FETAL-MATERNAL SOURCE
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机译:混合的胎儿来源的胎儿DNA序列的特定扩增
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摘要
The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective amplification of trophoblast/fetal specific sequences from DNA mixtures that contain a high proportion of non- trophoblast/fetal DNA. The invention also provides methods of using the amplified fetal DNA sequences for aneuploidy detection.
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