: Racemic 2-pipecoloxylidide is dissolved in lsopropyl alcohol, filtered through hiflow bed and washed twice ipa, filterd; residue is washed thrice with iph to gey dry solid dibenzoyl-2-pipecolinoxylidide-l-tartrte which is dissolved in water and toluence, heated and caustic lye is added, stirred to get two layers, form which organic layer is reacted with sodium hydroxide solution, TBAI and n-propyl bromide, heated to 70ºc and cooled; dm water is added with stirring and filtered; organic layer obtained is dried over sodium slurry, filter and dry to get ropivacaine base with chiral purity 99.5%; ropivacaine base and mibk are stirred, heated and IPA.HCI is added slowly, stirred, cooled to gert solid Ropivacaine hydrochloride. No. of Pages : 11 No. of Claims : 3
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