A NOVEL AND IMPROVED METHOD OF PREPARATION OF 4-2-(METHYL-2-PYRIDINYLAMINO)ETHOXY-BENZALDEHYDE - A KEY INTERMEDIATE OF ROSIGLITAZONE

摘要

(a) Reacting 2[methyl(pyridine-2-yl)amino]ethanol with 4-halobenzonitrile using a base in a solvent, to give 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile, (b) reacting a solution of 4-(2-[methyl(pyridine-2-yl)ami- no]ethoxy)benzonitrile in formic acid with Raney nickel in water ,to give 4-[2-(methyl-2-pyridinylamino)ethoxy]-benzaldehyde.