AN IMPROVED PROCESS FOR THE PREPARATION OF SALMETEROL XINAFOATE

摘要

The present invention relates to an improved process for the preparation of condensing [4-((6-bromohexyl)oxy)-butyl]-benzene with a salmeterol xinafoate by (aminomethyl)-4-hydroxy-1,3-benzenedimethanol in presence of aprotic solvent{oo afford salmetrol free base which on further reacted with 1-hydroxy-2-naphthoic acid give curde salmetrol, The obtained crude salmeterol was purified in a suitable solvents to give pure salmetrol xinafoate.