SUBSTITUTED-DIHYRO1,40XAZINO2,3,4-HIINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS

摘要

The present invention provides a substituted-dihydro[1,4]oxazino[2,3,4-hijindazole compound of formula I Formula Removed Wherein X is a bond, O, S, NR or CONR; m is 0 or an integer of 1; R is H or an optionally substituted alkyl group; R1 and R7 are each independently H or an optionally substituted alkyl group; R2 is an alkyl, cycloalkyl, aryl or heteroaryl group each group optionally substituted or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S; R3 and R4 are each independently H, or an optionally substituted alkyl group; n is 0 or an integer of 2, 3, 4, 5, or 6; R5 and R6 are each independently H or an alkyl, alkenyl, alkynyl or cycloalkyl, group each group optionally substituted or R5 and R6 may be taken together with the atom to which they are attached to form an optionally substituted 3-to 7-membered ring optionally containing an additional heteroatom selected from NR, O or S; Rs is H, halogen, OR9, or an optionally substituted alkyl group; and R9 is H, alkyl or haloalkyl; or a stereoisomer thereof or a pharmaceutically acceptable salt thereof.